As a bioinformatician, when you are given a new system (Mac, HPC, or any Linux environment), the first thing to do is probably to configure your work environment, install required tools, etc.
Here is what I did for the new Mac:
1. This step is optional. Apple changed to default shell to zsh since the last OS. If you like bash, you can change the default zsh shell from bash:
chsh -s /bin/bashwget https://repo.anaconda.com/miniconda/Miniconda3-latest-MacOSX-x86_64.sh
3. Install commonly used tools with bioconda:
# update bash (the one coming with MacOS is too old)conda install -c conda-forge bash
# samtools etc.conda install -c bioconda samtools plink plink2
# UCSC Kent Utilities etc.conda install -c bioconda ucsc-bedgraphtobigwig ucsc-wigtobigwig ucsc-liftover ucsc-bigwigsummary
# GNU utils etc.conda install -c conda-forge coreutils gawk wget gzip datamash parallel make readline sed
# R and R package etc.conda install -c r r-base
conda install -c r r-essentials
conda install -c r r-tidyverse
Life is much easier after conda!